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Thus, colonic histamine/H4R helps to create a neutrophil-attracting milieu that promotes neutrophil migration into the mucosa, where they are poised to damage the crypts and drive clinical severity

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Through the Cori cycle, the lactate produced in excess by aerobic glycolysis is converted into glucose and, as a result, there is a gain of energy by the cancer and a net loss of energy by the host (142)

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