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Ethics declarations Ethics approval and consent to participate The Ethics Committee of The Third Hospital of Qinhuangdao approved all experimental protocols

The GSH is recycled by glutathione reductase (GR) using NADPH from the pentose phosphate pathway

Alpha Lipoic Acid plays the role of antioxidants and Pycnogenol as fighting inflammation and preventing damage of skin by the environment

Pharmacologic activation of p53 triggers viral mimicry response thereby abolishing tumor immune evasion and promoting antitumor immunity

Treatment of MSRT1 cells with increasing IFN concentrations in vitro resulted in a significant increase in F4/80 expression (Fig