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A major component of the damaging effect of TNF- is the autocrine induction of the release of glutamate from microglia.[285] Experiments exposing immature rats to Roundup , whether via exposure to the dam during pregnancy and lactation or via acute exposure to the pup for 30 min, demonstrated lipid peroxidation and NMDA receptor activation in the hippocampus, indicative of oxidative stress and glutamate excitotoxicity.[59] Acute exposure increased the release of glutamate into the synaptic cleft, and depleted GSH

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