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Since cell physiology must not be compromised under the production conditions, metabolic alterations should be controlled in order to enable a proper functioning of the metabolic networks involved

Considering that the mRNA expression of TP53 decreased in iron-overloaded KGN (Fig

Iron overload increases the severity of inflammatory processes, in which there is not only a consistent relationship between seizures and inflammatory cytokines (IL-6, TNF-, and IFN, etc.) but also the inflammation itself generates increased iron deposits [7]

BMC Bioinformatics 5 , 113 (2004)

ALCAR functionally inhibits angiogenesis in vitro We have previously shown that ALCAR inhibits endothelial cells by regulating angiogenesis in hypoxic and inflammatory conditions in vitro and in vivo [30]