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PMID: 41188178 Sci Bull (Beijing)An engineered DNA aptamer-based PROTAC for precise therapy of p53-R175H hotspot mutant-driven cancer

PDI: 0.4 to 0.6

We found significantly lower mean Tajimas D for the top SNPs from the GWAS compared with background SNPs for three of the four traits (Figure 8) due to an excess of low frequency alleles (i.e., low MAFs), consistent with purifying selection (Paape et al., 2013)