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Musher 2012)

Innate immune memory: towards a better understanding of host defense mechanisms

To address these limitations, future research should prioritize: (1) developing more physiologically relevant preclinical models (e.g., humanized liver chimeras, diet-induced murine models with metabolic comorbidities) to better recapitulate human NAFLD pathophysiology

Welch C, Lusis AJ

105,265,302 Elevated serum uric acid levels heighten the risk of cardiovascular disease (CVD) mortality, potentially due to mechanisms by which hyperuricemia activates the renin-angiotensin system and induces hypertension