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151 MAPK promotes cell proliferation in PH In patients with PAH, abnormal activation of the MAPK pathway leads to excessive proliferation and disrupted apoptosis in PASMCs and PAECs, contributing to pulmonary vascular remodeling

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Ethical approval and consent to participate All experiments utilizing animal models conducted in our laboratory and referred to in this review adhered to the Guidelines for the Care and Use of Laboratory Animals as required by the National Institutes of Health (NIH Publication No

W represents a group selected from substituted or unsubstituted linear, branched or cyclical alkyls, aryls, substituted aryls, substituted or unsubstituted linear, branched or cyclical heteroalkyls, substituted or unsubstituted heteroaryls