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It is a quaternary ammonium compound that the body synthesizes from the amino acids lysine and methionine, primarily in the liver, kidneys, and brain

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5.1 Mechanism of intranasal delivery Since William Frey II proposed intranasal administration in 1991 (Frey, 1991), this technique has emerged as a novel, non-invasive delivery system, bypassing the BBB and the systemic first-pass effect, allowing rapid onset of action

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