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Nutrients 11, 1135

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Then through the Fenton reaction [Fentons chemistry refers to a series of reactions between peroxides and divalent ferrous salts, producing oxygen-centered free radicals (Winterbourn, 1995)], producing hydroxyl and peroxy radicals, then extracts oxygen atoms from PUFA diallyl carbon and induces PUFA-PLs peroxidation ( + , and then increasing LIP to enhance ferroptosis ( Mitochondria also make an important impact on regulating iron homeostasis

In this context, citrate is transported out of the mitochondria into the cytosol via the mitochondrial citrate carrier SLC25a1 and - with the help of ATP citrate lyase functions as an acetyl donor to support the generation of acetyl CoA and fatty acid-derived derivatives