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54, 55, 56, 57, 58 In humans, there are three main subtypes of TIM receptors (TIM-1, TIM-3, and TIM-4), each of which has confirmed PS interactions through a conserved N-terminal IgV extracellular domain

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Key limitations hindering clinical translation include: (1) Formula standardization gaps : Current research predominantly focuses on empirical or self-formulated TCM prescriptions, with insufficient validation of classical prescriptions through randomized controlled trials