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Cells undergoing ferroptosis have different morphological and metabolic characteristics from other known forms of cell death (such as apoptosis, necrotizing apoptosis, and pyroptosis) [15]

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Synthesizing these findings, we outline emerging combination strategies that concurrently target ferroptosis and cuproptosis, and discuss current challenges and future directions for translating these concepts into precision therapies for OSCC

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However, administration of much larger doses of cancer chemotherapy agents in rats, such as paclitaxel either as a single bolus (12.532 mg/kg) (Authier et al., 2007) or as cumulative doses (8 and 16 mg/kg once-weekly for 5 weeks) (Cavaletti et al., 1995) or bortezomib at 2.44.8 mg/kg (Cavaletti et al., 2007