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There are specific scenarios where combining these two forms of B12 might be considered, as part of a tailored treatment plan: Reducing Injection Frequency: For some individuals who require lifelong B12 due to malabsorption but dislike frequent injections, a doctor might explore if high-dose oral supplements can help maintain adequate levels between less frequent injections

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These include semi-solids (e.g., ointments and gels), solids (e.g., powders, inserts, and contact lenses), and hybrid systems (e.g., in situ gels), which offer improved drug retention and sustained release profiles