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pLenti/puro (+)3Flag HK2 S340/S788A, pLenti/puro (+)3Flag HK2 D209/D657A, RIPK1 S32A and RIPK1 S32E were generated using the QuikChange site-directed mutagenesis kit (Stratagene, La Jolla, CA)

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Diabetic nephropathy Patients with poorly controlled type 1 diabetes mellitus (T1DM) present with markedly enhanced pituitary GH-secretion rates, probably related to decreased hypothalamic somatostatin tone and exaggerated GH-responses to physiological and pharmacological stimuli [186, 187]