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10.3390/pharmaceutics15020451 59 PuigM

Thanks to the presence of GR, a single molecule of GSSG is reduced to two molecules of GSH, so that the presented method measures total GSH as the sum of reduced and oxidized GSH ([GSH] total = [GSH] + 2 x [GSSG]) (Rahman et al., 2007)

J.HamadyM.YatsunenkoT.CantarelB

nevertheless, it can be interpreted by viewing POF as a pathological aging phenomenon, given the depletion of ovarian reserve during POF

Chronic or repetitive stress can add to persistent dysregulation of HPA axis signaling and cortisol release, and is linked to depression and anxiety, brain atrophy, cognitive impairment, and dementia