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Omaveloxolone activates the Nrf2 pathway by blocking the ubiquitination and degradation of Nrf2 [9]

NAC plasma concentration-time profiles were described by a first-order absorption, one-compartment pharmacokinetic model

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Montalban-Bravo G, Bose P, Alvarado Y, Daver N, Ravandi F, Borthakur G, Takahashi K, Andreeff M , Cortes JE, DiNardo CD, Jabbour E, Kadia TM, Kornblau SM, Ohanian M, Pierola AA, Huang X, Nogueras-Gonzalez GM, Bodden K, Littles K, Pierce S, Bueso-Ramos CE, Kantarjian H, Garcia-Manero G