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10.3390/cells13110966 Cells 159 NelsonH.LeechC.KoppR.RoeM

As such, at early-disease stage, NKX21 overexpression might limit ROS levels needed to acquire additional oncogenic driver mutations and in this way function as a tumour suppressor, which could explain our observation that NKX21 overexpressing A549 cells engrafted to a lesser extent in the lungs at early-disease stage (Fig

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