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Similar inconsistent findings were also shown in other clinical studies (Scholze et al., 2014

mRNA-4157 (V940) is an mRNA-based personalized neoantigen therapy by encoding up to 34 tumor-specific antigens in a lipid nanoparticle formulation and tailored specifically for cancer patients, subsequently stimulating the immune system to produce reactive T cells targeting patient-specific tumor neoantigens, thereby achieving the goal of controlling and treating tumors

14 Other transmembrane proteins acting on TJs, such as claudins, junctional adhesion molecules (JAMs), and MAL and related proteins for vesicle trafficking and membrane link domain-3 (MarvelD3), were later discovered

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Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan