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Shortly after the original identification, the copper-binding role was established, and the conceptual framing shifted toward GHK as a copper-delivery peptide whose proliferation-supporting activity in the original assays reflected the role of copper in cellular biology rather than a direct growth-factor signaling activity in the classical sense

Redox Biol 59:102593 Shen Y, Zhang G, Wei C, Zhao P, Wang Y, Li M, Sun L (2025) Potential role and therapeutic implications of glutathione peroxidase 4 in the treatment of Alzheimers disease

ALA may also restore the activity of acetylcholinesterase and Na + , K + -ATPase