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Interestingly, the generation of R-2-HG from glutamine has been proven to occur rapidly in patient-derived chondrosarcoma cell lines harboring endogenous IDH mutations, indicating fundamental metabolic differences between cells that harbor IDH1/2 mutations and those that do not 121

In contrast, the constructs in the present study were introduced to a wild-type yeast strain

As the central enzyme of the endogenous lipogenesis pathway, fatty acid synthase (FAS) is directly involved in regulating lipid deposition, making it a critical marker for assessing dietary effects (Schroeder et al., 2021)

Role of increased n-acetylaspartate levels in cancer

2024), we performed an in vivo rat study and conducted multi-omic (metabolomic, transcriptomic, proteomic and lipidomic) assessment of liver, which was anchored with histopathology and clinical chemistry analysis