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G6PD is the major source of the cytosolic NADPH pool (see the Metabolic Sources and Cellular Distribution of the NAD(H) and NADP(H) Couples section)

Acknowledgements This work was supported by the National Natural Science Foundation of China (82273092) to LFF and Natural Science Foundation in Zhejiang province (LD22H160003) to XW

(2021) 45(1):e15024

Compared to healthy controls, SCD patients have significantly lower erythrocyte GSH and cysteine concentrations 12 and a faster rate of GSH synthesis, suggesting that the endogenous cysteine supply is insufficient to meet all anabolic demands

Distribution studies showed that in rabbits, following inhalation or injection, the highest concentrations of morpholine were found in the kidney, whereas, in rats, high concentrations were found in muscle