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KaplanMeier survival analysis revealed a significant difference in the progression-free interval between the two groups (log-rank p = 0.0019), with cats in the high UGCR group showing a shorter time to progression (Figure 5)

292 Regarding the dual effects of SIRT1 deacetylation on HIF-1, for instance, under aging or hypoxic conditions, decreased SIRT1 expression and activity has been reported to lead to enhanced acetylation of HIF-1 at Lys709, which upregulates profibrotic and proapoptotic genes, ultimately resulting in tubulointerstitial damage characterized by fibrosis and apoptosis, 293 which means that pharmacological activation of SIRT1 to inhibit HIF-1 activity is proposed as a potential therapeutic strategy for mitigating age-related renal injury

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10.1016/j.ijbiomac.2018.07.082 152 WuZ.-W.LiuX.-C.QuanC.-X.TaoX.-Y.Yi-LuoN.ZhaoX.-F.et al (2025)

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