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however the mechanism underlying this action was unknown

doi:10.1016/j.soard.2022.08.013 Balasubaramaniam V, Pouwels S

Several mechanisms have been reported as responsible for cisplatin resistance, such as reduced drug uptake by a decrease in CTR1 expression, increased efflux by ABC transporters, augmented induction of stress response chaperones, induction of autophagy, inactivation of apoptosis pathway signaling, inactivation by thiol-containing proteins, and functional changes in DNA repair pathways 6,7,8,9,10,11