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Biomaterials 27, 59355943.10.1016/j.biomaterials.2006.08.029 125 RodellC

Within the nucleus, NRF2 binds to promoter regions of target genes which contain antioxidant response element (ARE) sequences, ultimately inducing the transcription of cytoprotective genes, i.e., those encoding for phase II detoxification enzymes and antioxidants

J Endocrinol 184:1128 Gulbenkian S, Merighi A, Wharton J, Varndell IM, Polak JM (1986) Ultrastructural evidence for the coexistence of calcitonin gene-related peptide and substance P in secretory vesicles of peripheral nerves in the guinea pig

You may experience a lightening or darkening of the affected skin, though in most cases this returns to normal after six months

Broad Gene-Expression Signal (experimental): Reported studies show changes in gene sets tied to ECM remodeling, antioxidant defenses, inflammatory signaling, and nervous-system pathways