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Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis identified several significantly enriched pathways, including the MAPK signaling pathway (Wang et al., 2023), p53 signaling pathway (Qu et al., 2021) (Figure 4D), all of which are closely associated with oxidative stress and ferroptosis

Although these results seemed promising, the study had significant limitations in terms of non-randomization, failure to report the severity of ALF, and the unstandardized protocol for the administration of NAC regarding body weight adjustments and administration as a continuous infusion similar to previous studies

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