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The free margin of the nail leaves the nail bed, producing a concave or wavy margin at the line of contact

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120 Patients with the following risk factors need monitoring for the development of thrombocytopenia 115,118,121,120 : Prolonged treatment course greater than 14 days Underlying disease with a predisposition to hematologic abnormalities Renal dysfunction, CrCl less than 30 ml/min, and dialysis