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Platelet Mitochondria Transplantation rescues Hypoxia/Reoxygenation-Induced mitochondrial dysfunction and neuronal cell death involving the FUNDC2/PIP3/Akt/FOXO3a Axis [J]

528,529 Metformin, a traditional diabetes drug, upregulated the expression of mitophagy genes, such as PINK , Parkin , and Mfn2 , while at the same time effectively reducing damaged mitochondria after administration, indicating a great potential of metformin as a mitophagy activator

NK cells can eliminate abnormal joint cells or pathogens via perforin and granzymes, and they secrete cytokines such as IFN- and TNF- to regulate immunity and inflammation (1, 114, 115)

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Interestingly, repeated NFT treatment resulted in higher GCLC levels in the days after removal of the compound and an elevated induction in response to a second exposure to NFT, similar to the previously published pattern of sulfiredoxin synthesis upon repeated exposure to DEM or tert -butylhydroquinone (Bischoff et al