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At Week 8, patients in the combination treatment group showed significantly greater improvement in total number of lesions compared to the other study groups, suggesting that antibiotic treatment with adjuvant probiotics may offer synergistic anti-inflammatory effects and reduce potential gastrointestinal adverse effects of prolonged antibiotic therapy

Inhibin A and B as markers of menopause: a five-year prospective longitudinal study of hormonal changes during the menopausal transition

So in a way, you got at this question because of the chicken-and-egg and what happens first, and you got to the temporal saying, which happened first as you said, the leak before you could see evidence of inflammation and being able to study this of course in the experimental model, which you couldn't really do in people