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10.1016/j.exger.2022.112064 114 TakeshitaY.SatoR.KandaT

These variants equally preserved their GSH-transferase activity, suggesting the importance of additional factors in the modulation of the negative log of GSHs acid dissociation constant (p K a ), including the ability to optimally arrange the well-described electron-sharing network which generates a positively charged electrostatic field in the G-site of GSTs 40,41