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International journal of obesity , 29 (12), pp.1402-1412

Louis, MO, USA), tetrahydrofuran (C 4 H 8 O, 99.9%,Cornaredo MI, Italy), donepezil hydrochloride (C 24 H 30 ClNO 3 , 98% (HPLC), Sigma Aldrich, Lu Wan Qu, Shanghai, China), streptozotocin (C 8 H 15 N 3 O 7 , 98% (HPLC), 265.22 g/mol, Sigma Aldrich, Saint Louis, MO, USA), citrate buffer (0.1 M, pH 4.5, Biodiagnostic, Egypt), O-acetylcholine iodide (C 7 H 16 INO 2 , 99%, 273.12 g/mol, BDH chemicals, Poole, Dorset, England), 5,5-Dithio-bis(2-nitrobenzoic acid) (C 14 H 8 N 2 O 8 S 2 , 98%, 396.36 g/mol, Corsham, England), ELISA kit for brain derived neurotrophic factor (BDNF) (Elabscience, Wuhan, Hubei, China), Commercial kits from biodiagnostic, Egypt were used for the measurement of MDA, GSH and SOD

Excessive accumulation of subcutaneous adipose tissue is associated with various diseases

TB-500 acts on actin filament modulation, improving cellular migration, wound healing, and overall tissue recovery

(Wilmington, MA, USA), maintained and bred at the animal house of the Fondazione IRCCS Istituto Neurologico Carlo Besta in compliance with institutional guidelines