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Furthermore, during the functional neuroimaging phase, it appeared that MC4R agonism possibly amplified activity in the cerebellar and supplementary motor areas while possibly deactivating the secondary somatosensory cortex, specifically when the subjects were exposed to erotic stimuli, in contrast to the placebo

Clinical studies are needed to evaluate whether these in vitro findings translate to measurable adverse outcomes in humans, particularly with chronic use

UN: Conceptualization, Project administration, Supervision, Validation, Writing original draft, Writing review & editing

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World J Surg 2007 Jan;31(1):171-174