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As certain cytotoxic antineoplastic agents, such as anthracyclines, generate reactive oxygen species as a by-product of their mechanism of action, we examined whether redox protein expression was involved in the response to anthracycline-based chemotherapy and with clinical outcome
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RESULTS Ubx exhibits in vivo moonlighting functions beyond its DNA-binding ability Ubx binds RNA 21 and yet, the functional implications of this association are unknown

Abbreviations ARE: Antioxidant response element BDNF: brain-derived neutrotrophic factor CAM: cell adhesion molecule IGF-I: insulin-like growth factor I IL: interleukin IL-1R: interleukin-1 membrane receptor IL-1RA: interleukin-1 receptor antagonist Keap1: kelch-like erythroid cell-derived protein with CNC homology associated protein 1 MMP: matrix metalloproteinase iNOS: nitric oxide synthase type II ICAM-1: intracellular adhesion molecule 1 MCAO: middle cerebral artery occlusion MCP-1: monocyte chemoattractant protein-1 NOS: nitric oxide synthase Nrf2: nuclear factor erythroid-related factor 2 ROS: reactive oxygen species rt-PA: recombinant tissue plasminogen activator T reg : regulatory T lymphocytes sICAM-1: soluble intracellular adhesion molecule 1 SOD: superoxide dismutase t-BuOOH: tert-butylhydroperoxide tBHQ: tert-butylhydroquinone TGF: transforming growth factor TNF-: tumor necrosis factor-