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The disability rate increases dramatically with the course of the disease, reaching 70% at 3 years in untreated patients, and the systemic complications reduce life expectancy by 1015 years (2)

Through microbial action, these substrates are converted into various metabolites that may be advantageous or harmful to the host, including SCFAs, choline metabolites, vitamins, lipids, phenolic compounds, cortisol, genetic materials, and phytoestrogens (8486)

The level of AGEs in the urine possibly indicates that in vivo AGE levels are positively correlated with dietary glycemic load (Maasen et al

A hypothesis in this regard explains that the -catenin signaling pathway plays a role in renal carcinogenesis, including Cd-induced nephrocarcinogenesis

Publicly available datasets used in this study are at DepMap ( Extended Data Fig