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Rapid acceleration/deceleration induces shearing forces on the axons which cause stretching and tearing damage

Fluorescence images were obtained with confocal microscope Nikon A1Rsi (Nikon, Germany) microscope with Plan Plan Apo 10x/0.45 DIC N1, Plan Apo VC 20x/0.75 DIC N2, Apo 40x/1.25 WI S DIC N2, Plan Apo VC 60x/1.4 Oil DIC N2 and Plan Apo VC 100x/1.4 Oil DIC N2 lenses and with Nikon NIS Elements AR 5.21.01 64-bit software (Nikon, Germany) or with confocal microscope LEICA Stellaris 8 (Leica Camera, Germany) with HC PL APO 20x/0.75 CS2 Air, HC PL IRAPO 40x/1.10 W CORR, PL APO 63x/1.20 W CORR CS2 or PL APO 63x/1.20 W CORR CS2 lenses and with Leica LAS X Office 1.4.7 64-bit software (Leica Camera, Germany) or with light sheet fluorescence microscopy (LSFM) ZEISS Lightsheet 7 (Zeiss, Germany) with W Plan-APO 20x/1,0 DIC lens, in water chamber and with ZEN Black 3.1 software for imaging and ZEN Blue 3.1 software for data analysis (Zeiss, Germany)

Unlike permethrin, many effective repellants are safe to apply to skin including N,N -diethyl- m -toluamide (DEET), picaridin, ethyl-3-(N-n-butyl-N-acetal) aminopropionate (IR3535), oil of lemon eucalyptus, p-methane-3,8-diol (PMD), and 2-undecanone

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Multiple studies have shown that this therapeutic resistance can be reversed by direct targeting of SLC7A11 (9092)