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Aroda VR, Edelstein SL, Goldberg RB, Knowler WC, Marcovina SM, Orchard TJ et al (2016) Long-term metformin use and vitamin B12 deficiency in the Diabetes Prevention Program Outcomes Study

Moreover, its ability to reduce mitochondrial dysfunction in experimental models of bile acid and alcohol-induced pancreatitis suggests it could be beneficial in preventing AP exacerbations due to mitochondrial injuries (57)

We have no long-term safety data

How a combination protocol is structured in practice Where the combination is clinically appropriate, the protocol structure follows the available pharmacology of each compound