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GI symptoms, including excessive salivation, dysphagia, constipation, esophageal motility disorders, and gastric abnormalities, occur many years before the appearance of motor symptoms and may be associated with an increased risk of developing PD [112]

249,251 Dyslipidemia also affects Schwann cells, leading to mitochondrial dysfunction, endoplasmic reticulum stress, and oxidative stress, ultimately causing cell death

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Persistent activation and accumulation of myofibroblasts without resolution of the reparative response underlies the progressive nature of fibrotic reactions in injured tissue [5]

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