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STEP 2, conducted in adults with type 2 diabetes, showed 9.6% weight loss with Semaglutide 2.4 mg (Davies et al., Lancet 2021

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The results demonstrated improved cognitive performance, reduced oxidative stress, and neuroinflammation alongside histological improvements, suggesting that the neuroprotective and cognitive-preserving effects of ttozasertib confer neuroprotection, likely via the FGF1/PI3K/Akt signaling axis

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Negrini S, Emmi G, Greco M, Borro M, Sardanelli F, Murdaca G, et al