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Therefore, in line with 3 R animal experimental principles, we chose to conduct our proof-of-concept study directly in elephants since an in-target-species trial in a real-world setting provides an accurate reflection of the vaccines safety and immunogenicity, avoiding reliance on models that poorly recapitulate elephant immunology

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Thus, patients in the immune-tolerant phase are generally children or young adults from regions where HBV is endemic

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Hydrogen bond analysis showed that the number of interactions between sulforaphane and MMP-9 ranged from 0 to 4, with an average of approximately 1 hydrogen bond maintained throughout the trajectory (Fig