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2393-C TWO MEALS PER PERIOD PREVENTS FATTY LIVER BY STIMULATING ENERGY EXPENDITURE Pamela Mattar 1,2 , Andressa Reginato 2 , Christian Lavados 2 , Nuria Martinez-Lopez 1,2 , Mridul Sharma 1,2 , Gary Schwartz 2 , Prashant Rajbhandari 3 and Rajat Singh 1,2,4 , (1)University of California, Los Angeles, (2)Albert Einstein College of Medicine, (3)Diabetes, Obesity, Metabolism Institute, Icahn School of Medicine at Mount Sinai, (4)Liver Basic Research Center at University of California Los Angeles Background : Intermittent fasting has been proposed as a non-invasive approach to reduce body weight and promote insulin sensitivity

Microbiome 13 (1), 16

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Molecular dynamics (MD) simulation studies Reason for the selection of specific targets Among all the targets, the SIRT3, FOXO1, and PPARGC1A (PGC-1) were found to have the highest number of edge counts, numerous studies have reported that solely upregulation of SIRT3 can potentiate the activation of FOXO1 (antioxidant-gene) and PGC-1, whereas the activation of FOXO1 downregulates the ROS level, and oxidative stress via mitochondrial access 29,30,31

Lu H, Du W, Ren L, Hamblin MH, Becker RC, Chen YE