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The problem is that the molecule in those studies is not the molecule sold as TB-500

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Surprisingly, a majority of Nrf2 dependent antioxidant systems such as GSH biosynthesis/recycling ( e.g., GSS, GPX1, GPX4, GSTP1), thioredoxins ( e.g., TXNRD2), and peroxiredoxins (PRDX6) were downregulated upon treatment with Vs alone or Vs plus PMA (Fig 5C), indicating an adverse influence of Vs on U1 cells

These data indicate that GFP-Cys3 localizes to the nucleus in complex medium (sulfur limiting), and it is probably active in this condition, inducing the sulfur uptake

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