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Some have strong clinical evidence

3 Increased expression of the receptor for AGEs (RAGE) and its activating ligands

However, another study demonstrates that IGF-IR overexpression is essential for leukemia-initiating cell activity in T-ALL [15]

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Evaluation of caspase-3 activation Caspase-3 activation during the early stages of PMA-induced NET formation was evaluated using the CellEvent Caspase-3/7 Green Detection Reagent (C10423, Invitrogen) and an active caspase-3-specific antibody (570524, BD Biosciences)