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Strategies to expand the therapeutic potential of superoxide dismutase by exploiting delivery approaches

Increased frequency of serum liver transaminases exceeding five times the upper normal limit (7/32 versus 0/22, p = 0.0335), increased serum alkaline phosphatase (median 427 versus 214 IU/L, p = 0.0005) and increased GT (median 213 versus 60 IU/mL, p = 0.0001)

While different studies suggest that primary drug-target damage may activate processes such as envelopes stress response and programmed cell death, leading to ROS accumulation (Lobritz et al., 2015