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There is also some evidence that glutathione levels may be decreased in critical illness and in sepsis [13,14]

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The analysis employed a one-way analysis of variance (ANOVA) for normally distributed continuous variables, while the Mann-Whitney U test or Kruskal-Wallis test was used for non-normally distributed data

This so-called autocrine loop of ROS by HSCs is regarded as mechanism corresponding to the autocrine loop of TGF- which HSCs produce in response to this cytokine with an increased collagen expression in the injured liver (Itagaki et al., 2005)