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Effects of arsenite on glutamate metabolism in primary cultured astrocytes

Access this article Similar content being viewed by others Data Availability Not applicable Abbreviations AGT: Alanine-glyoxylate aminotransferase AIP: Acute intermittent porphyria ALA: Delta-aminolevulinic acid ALAD: Delta-aminolevulinic acid dehydratase ALAS1: Delta-aminolevulinic acid synthase 1 AS: Aspergers syndrome ASD: Autism spectrum disorder ATEC: Autism Treatment Evaluation Checklist CBS: Cystathionine beta-synthase Cd: Cadmium CGL: Cystathionine-gamma lyase CPOX: Coproporphyrinogen III oxidase DHLA: Dihydrolipoic acid DMPS: Dimercaptopropane-1-sulfonic acid DMSA: Dimercaptosuccinic acid DSM-5: Diagnostic and Statistical Manual of Mental Disorders EDTA: Ethylenediaminetetraacetic acid Hg: Mercury Mg: Magnesium PBGS: Porphobilinogen synthase Pb: Lead TMP: Thiamine monophosphate TPP: Thiamine pyrophosphate TTFD: Thiamine tetrahydrofurfuryl disulfide UROD: Uroporphyrin decarboxylase Zn: Zinc References American Psychiatric Association (2022) Diagnostic and statistical manual of mental disorders, fifth edition, text revision

Its molecular formula is C 27 H 30 O 10 , and it possesses several pharmacological activities, such as antioxidant stress, anti-neuroinflammatory, anti-osteoporotic, and anti-cancer properties ( D ) of 1.033 10 4 M

The primary sources of NADPH in tumor cells characterized by disrupted mechanisms involve (i) the pentose phosphate pathway (PPP), which is essential for maintaining cytosolic NADPH levels