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In rare cases, improper application of topical creams may cause rebound hyperpigmentation or skin thinning

Supplementation with GSH is generally ineffective at increasing cellular glutathione levels because most human cells cannot uptake extracellular GSH due to the lack of the membrane-bound ectoenzyme -glutamyltranspeptidase (-GT) or due to an unfavorable concentration gradient across the cell membrane10,16