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From first administration in humans to regulatory approval: what are the next steps, and why can the journey take years

Neurological Exploration: Preclinical models have examined potential effects on neuroprotection, including recovery after traumatic brain injury or spinal cord injury

[40] With the knowledge of the dopaminergic stimulant effects of the adamantane derivatives, bromantane, which is 2-(4-bromophenylamino) adamantane, was developed in the 1980s at the Zakusov State Institute of Pharmacology, USSR Academy of Medical Sciences (now the Russian Academy of Medical Sciences) in Moscow as "a drug having psychoactivating and adaptogen properties under complicated conditions (hypoxia, high environmental temperature, physical overfatigue, emotional stress, etc.)"

Their work forms the foundation of scientific understanding and is widely cited in peer-reviewed journals

"Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations"