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Further, the mutant atgsnor13 was also perturbed in thermotolerance and resistance to paraquat (1,1 -dimethyl-4,4 -bipyridinium dichloride), which induces the production of superoxide and H 2 O 2 in wild type leaves ( Arabidopsis GSNOR1/HOT5/PAR-2 gene not only regulates SA signaling and thermotolerance by modulating the intracellular SNO level, but also acts downstream of superoxide to regulate cell death

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beyond that trial and the halted Phase 2 lipodystrophy study, there are no completed human trials measuring body composition, strength, or long-term safety outcomes, so evidence for bodybuilding-related benefit claims remains preliminary and largely extrapolated from the hormone's known biology rather than from direct testing of CJC-1295