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But I definitely think that dysregulation of the Sigma-1 system should be highly suspect for discontinuation problems from SSRIs, especially if what youre withdrawing from is a powerful Sigma-1 activator

J.MayesS

10.1016/j.neurobiolaging.2010.03.008 200 ShehadehJ.FernandesH

However, with the increasing clinical application of methotrexate, side effects and deficiencies as intestinal inflammation and pulmonary fibrosis gradually appeared during the treatment