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Via this metabolic adaptation, cells can continually generate TCA metabolites, such as -KG and citrate, which are converted to cytosolic acetyl-CoA for lipid biosynthesis (Fig

No increase in chromosome aberrations was reported in one study (Galloway et al., 1987), while chromosome breakage was reported in another study at cytotoxic concentrations (Au et al., 1980)

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Current challenges in NADs development Unlike traditional small molecules and antibody drugs that exert their pharmacological effects on proteins, most NADs directly regulate gene expression, offering a broader range of targets