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PMID: 21548867 [2] Chang CH, et al

The peptide selectively accumulates in the inner mitochondrial membrane where it binds to cardiolipin, a specialized phospholipid essential for organizing electron transport chain supercomplexes and maintaining cristae structure [2][7]

Unsaturated VPA metabolites (4-en-VPA and 2, 4-dien-VPA) are potent inducers of microvesicular steatosis in rats, whereas VPA itself failed to induce discernible liver lesions at near lethal doses [60]

5.2 Model systems Animal models are indispensable tools for delineating the functions of the SLC7 family and offer invaluable perspectives on the transporters roles in metabolic disorders such as diabetes