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Lasho, Terra L

Interestingly, increased expression of proteins related to mitochondrial import and transport in the OXPHOS pathway was also seen in a preclinical mouse model of anxiety, a disorder that is highly comorbid with depression ( The mechanisms by which environmental stress negatively impacts the brain are still not fully understood

In this regard, a key mode of action to explain this relationship is via glucose transporter type 1 (GLUT1) which increases uptake of the oxidized form of ascorbic acid, dehydroascorbate and subsequently depletes glutathione (Yun et al., 2015)

[DOI] [PMC free article] [PubMed] [Google Scholar] 152.Ried K., Travica N., Sali A

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